Iodine 1 therapy is usually given in a hospital outpatients department or private radiology practice that offers nuclear medicine services. The precise setting for region of interest roi and gamma ray counts acquiring system of gamma camera easily determines the timedependent gross counts in any particular roi by making in vivo measurement of various patients. Pdf conjugate view gamma camera method for estimating. Store and dispose of sodium iodide i 1 in compliance with the appropriate regulations of the government agency authorized to license the use of this radionuclide. Rp gn009 safe working with iodine1 risk iodine1 is a beta and gamma emitter. Clinical journal of oncology nursing volume 12, number 6 iodine1 treatment for thyroid cancer and hyperthyroidism 905 issa a. Quantification of iodine1 distribution by gamma camera. Thyroid uptake measurement i123 or i1 as sodium iodide. A gamma camera with a pinhole or parallel collimator may be substituted for an uptake probe 15. Discard unused capsules after all sodium iodide i 1solution has been dispensed or expired.
Pdf quantification of radioactivity by planar gammacamera. Ngamma iodine1 is produced octovial by the irradiation of tellurium other vial options may be available. Introduction to radiation canadian nuclear safety commission. The principal gamma emission of 364 kev is considerably higher than the ideal for imaging with gamma cameras. About 70% of activity inhaled is deposited in the body and about 30% of that is deposited in the thyroid. The optimal method for determining iodine 1 treatment doses remains controversial. Quantification of radioactivity by planar gammacamera images, a promoted method of absorbed dose in the thyroid after iodine1 treatment article pdf available in scientific reports 81. Iodine 129 is present in spent nuclear fuel, highlevel radioactive wastes. The revised t eff of 1i is determined from many in. Iodide solutions are easily oxidized and the elemental iodine will become airborne. Pdf conjugate view gamma camera method for estimating tumor. Determination of gamma camera calibration factors for quantitation of therapeutic radioisotopes wei zhao1,2, pedro l. This methodology assumes a similar biological halflife of iodine, whereas in reality a large variation in biological halflife is observed. Although they can be stopped by a thin sheet of aluminum, beta particles can penetrate the dead skin layer, potentially causing burns.
Purpose iodine 123 is a pure gamma emitter and has excellent characteristics for imaging with modern scintillation cameras. To receive your continuing education credit, you must answer all of the questions. Photons used for detection and imaging of i 1 have an energy of 364. Superiority of iodine123 compared with iodine1 scanning. It is associated with nuclear energy, medical diagnostic and treatment procedures, and natural gas production. Perchlorate washout test may be used to detect iodide organification defects 18,19. Examples of gamma emitters include iodine 1, cesium7, cobalt60, radium226 and technetium99m. Iodine1 therapy is usually given in a hospital outpatients department or private radiology practice that offers nuclear medicine services. Determination of gamma camera calibration factors for. I 1 a iodine i 1 decays by beta emission and associated gamma emission with a physical halflife of 8. The halflife is 8 days, so over the likely period of use of the material, there is not a large reduction in activity. Based functional materials and devices, institute of functional nano and soft materials funsom, soochow university, 199 renai road, suzhou, 215123. It has a radioactive decay halflife of about eight days. A gamma camera may be substitituted for a dedicated uptake probe.
Complete the evaluation questionnaire and posttest, including your name, mailing address, phone number, and email address, if available. Planar scintigraphy used in nuclear medicine imaging emission imaging radioactive source inside patients body in both spect and planar scintigraphy radiation source used mainly 99 a 140 kev rays hence the name gamma camera. Quantification of radioactivity by planar gamma camera images, a promoted method of absorbed dose in the thyroid after iodine 1 treatment. Quantification of radioactivity by planar gammacamera images. Quantification of iodine1 distribution by gamma camera imaging alan green 1 european journal of nuclear medicine volume 18, page 144 1991 cite this article. On the first two days of the procedure, you will be administered a dose of thyrogen via an intramuscular injection. Empirical 1 iodine therapy in thyrotoxicosis based on.
Gamma decay generally does not affect the mass or atomic number of a radioisotope. That is, about one atom of iodine 129 and three atoms of iodine 1 are produced per 100 fissions. Imaging and detectors for medical physics lecture 5. Thyroid uptake measurement i 123 or i 1 as sodium iodide overview the thyroid uptake measurement measures the metabolic activity of the thyroid gland as reflected by its extraction of iodine from the blood. Radioprotection using iodine1 for thyroid cancer and. Iodine 1 decays by beta emission and has a halflife of 8. Proposal of a methodology for individualized iodine1. N gamma iodine 1 is produced octovial by the irradiation of tellurium other vial options may be available. Aug 23, 2018 radioactive iodine i1 can be used in medical therapies as a treatment and a diagnostic tool. Thyroid uptake measurements may be determined using tc99mpertechnetate 17. Conjugate view gamma camera method for estimating tumor uptake of iodine1 metaiodobenzylguanidine article pdf available in journal of nuclear medicine 294. This study compared the 123i thyroid uptake measurements obtained from a gamma camera fitted with a lowenergy allpurpose leap collimator to those obtained from a thyroid uptake probe and gamma camera fitted with a pinhole ph collimator.
Quantification of radioactivity by planar gammacamera images, a promoted method of absorbed dose in the thyroid after iodine1 treatment. A biokinetic model of iodine in the thyroid was developed and applied to a casecontrol study of hyperthyroid cat undertaken the nai 1 dose administration using a gamma camera 8slice ct with the in vivo study. It is most commonly used in the treatment of hyperthyroidism due to graves disease or a nodule. The major advantages of 1 i are its low price and ready availability. The gamma ray will penetrate tissue very effectively without excessive radiation dose. Alshakhrah, phd radioiodine iodine1, or i1 therapy has been used successfully for thyroid therapy for more than 50 years. Our patients received 10 mci or 15 mci of oral 1 i on the basis of the % uptake of the thyroid gland by standard gamma camera imaging. I1 fact sheet iodine1 n, gamma radiochemical sodium. The number of nuclear disintegrations in a radioactive material per unit time is called the activity. Uribe3, marjorie gonzalez4, jeanmathieu beauregard5,6, yuni k. However, few studies have suggested that high 1 i uptake can be associated with treatment failure with 1 i. I1 radionuclide fact sheet stanford environmental health. Effective half life of iodine for five thyroidectomy. Dec 17, 2016 radionuclide therapy using i 1 is commonly used for the treatment of benign thyroid diseases.
Quantification of radioactivity by planar gammacamera. Effective half life of iodine for five thyroidectomy patients. The goal of this study was to compare the performance of i123 and i 1 as imaging agents for wholebody scanning in patients with differentiated thyroid cancer undergoing ablation for thyroid remnants after initial surgery. Measurement of iodine123 thyroid uptake using a gamma camera. The energies of both are significant, so quite high dose rates are emitted by this nuclide, and the gamma radiation is quite penetrating. It is employed in medicine to monitor thyroid gland functioning, to treat goitre and thyroid cancer, and to locate tumours of the brain and of the liver. It gives a much lower radiation dose to the patient and the gamma ray energy of 159 kev is ideally suited for use in a gamma camera. It is also used in investigations to trace the course. The therapeutic dose to be administered is calculated based on the type of disease, the volume of the thyroid, and the measured uptake percentage. Jan 01, 2020 the sodium iodide i1 should be stored between 2c and 25c 36f and 77f.
Pdf quantification of radioactivity by planar gamma. For the siemens diacam gamma camera system, the experiments were developed with a pinholetype lead collimator. The fission yield of iodine 129 is about 1% and the yield of iodine 1 is close to 3%. Factors predicting treatment failure in patients treated with.
Sodium iodide i 1 fda prescribing information, side. Quality assurance testing of gamma camera and spect systems. For the diacam gamma camera system with a pinhole lead collimator, without reducing ring table 3 shows the calibration factors for 1 i and uncertainties associated with the respective distance between the detector and the phantom. Quantification of iodine 1 distribution by gamma camera imaging alan green 1 european journal of nuclear medicine volume 18, page 144 1991 cite this article. Cancer in the case of cancer, following removal of the thyroid, a large dose of radioactive iodine may be prescribed to completely ablate destroy any remaining thyroid tissue in the thyroid area. Iodine 1 1i, i 1 is an important radioisotope of iodine discovered by glenn seaborg and john livingood in 1938 at the university of california, berkeley. Iodine1 decays by beta emission and has a halflife of 8. Conjugate view gamma camera method for estimating tumor uptake of iodine1 metaiodobenzylguanidine article pdf available in journal of nuclear.
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